- https://www.cells.es/ca/actualitat/agenda/esdeveniments-publics-dalba/alba-ii-colloquium-1-cryo-em-structure-of-helicobacter-pylori-urease
- ALBA II Colloquium #1 - "Cryo-EM structure of Helicobacter pylori urease...
- 2021-01-25T11:00:00+01:00
- 2021-01-25T12:00:00+01:00
- Cryo-EM structure of Helicobacter pylori urease with a novel inhibitor in the active site at 2.0 Å resolution, by Eva Cunha (University of Oslo Centre for Molecular Medicine Norway)
- Què
- events
- Quan
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Gen 25, 2021
de 11:00 a 12:00 (Europe/Madrid / UTC100) - On
- ALBA (virtual event by Zoom)
- Nom de contacte
- ihernandez@cells.es
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Infection of the human stomach by *Helicobacter pylori* remains a worldwide problem and greatly contributes to peptic ulcer disease and gastric cancer. Without active intervention approximately 50% of the world population will continue to be infected with this gastric pathogen. Current eradication, called triple therapy, entails a proton-pump inhibitor and two broadband antibiotics, however resistance to either clarithromycin or metronidazole is greater than 25% and rising. Therefore, there is an urgent need for a targeted, high-specificity eradication drug.
Gastric infection by *H. pylori* depends on the expression of a nickel-dependent urease in the cytoplasm of the bacteria. Here, we report the 2.0 Å resolution structure of the 1.1 MDa urease in complex with a novel inhibitor by cryo-electron microscopy and compare it to a b-mercaptoethanol-inhibited structure at 2.5 Å resolution. The structural information is of sufficient detail to aid in the development of inhibitors with high specificity and affinity.
About ALBA II Colloquium
The series ALBA II Colloquium, addressed to the scientific user's community of synchrotron radiation, is aimed at inspiring and promoting fruitful ideas and information exchange about the future development of ALBA II facility.
