Local Directional Resolution: Its impact in map validation, map sharpening and beyond

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Prof. J.M. Carazo from CNB-CSIC
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events
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Jul 26, 2019
de 11:45 a 13:00 (Europe/Madrid / UTC200)
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ALBA Synchrotron, Marie Curie Meeting Room
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935924353
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Abstract

Expecting to fully engage equally deep Physicists and Biologists, he will introduce the notion of "how good a macromolecular CyoEM map" is, addressing this question in a totally new way in the field, by providing a resolution tensor per CryoEM voxel map (instead of just a number, the so called "local resolution"). The mathematical beauty of this tensor representation will immediately open a new university of opportunities for experimentalists in CryoEM(clearly impacting Pharma), with the capability to assess the quality of the map from the map itself (without the images), the alignment errors, the presence of problematic directions..... and much more. he will present the main concepts and applications in a practical manner, with a minimum of mathematical support. 

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