Image of XAIRA beamline at the ALBA Synchrotron.

In 2025 the ALBA Synchrotron joined the pan-European distributed research infrastructure that provides open access to cutting edge technologies and methods and fosters the development and network in structural biology.

Instruct-ERIC brings together leading research organizations and facilities from 17 European countries and organizations. It enables scientists to access around 100 advanced structural biology platforms, specialized training, and scientific-technical services, from sample preparation to structural analysis to computation and AI tools, as listed in the Instruct technology catalogue.

The ALBA Synchrotron joined Instruct in the recent expansion of the Spanish Center, Instruct-ES, together with the CSIC-owned cryo-TEM installed at ALBA, teaming up with the other Spanish nodes, like the CNB-CSIC, Biofisika, CIC-Biogune, and the the Spanish NMR distributed infrastructure.

Regarding structural studies at macromolecular level, ALBA now offers access via Instruct to the protein production and fragment-based screening platform, and the two macromolecular crystallography beamlines, XALOC and XAIRA, which support jet, in-situ and fixed-target serial crystallography experiments.

For studies at cellular level, ALBA opens this access to the soft X-ray transmission microscope at MISTRAL beamline to image the 3D cellular ultrastructure at 30 nm resolution in volumes of around 10x10x10 microns. This X-ray microscope can be coupled with sample preparation tools and the 3D-cryo-SIM super resolution microscope for better sample targeting, high throughput and correlation with confocal studies.

By joining Instruct-ERIC, the ALBA Synchrotron expands its engagement in the international scientific ecosystem and significantly increases its impact in structural biology, biotechnology and biomedicine studies.

This membership opens new opportunities for the national scientific community, fostering stronger integration and closer interaction with the international research community.